What is tissue engineering
Anthony
Atala, M.D., is the W.H. Boyce Professor and Director of the Wake Forest
Institute for Regenerative Medicine,
and Chair of the Department of Urology at the Wake Forest
University School of Medicine in North Carolina.Regenerative medicine is "a practice that aims to refurbish
diseased or damaged tissue using the body's own healthy cells." Atala was born in Peru in 1958, grew up in Boca Raton, Florida. Atala
attended the University of Miami and
has an undergraduate degree in Psychology. He went to medical school at
the University of
Louisville where
he also completed his residency in urology. He was a fellow at the Harvard Medical School affiliated
Children's Hospital Boston from 1990-1992 where he trained under world renowned
pediatric urologic surgeons Alan Retik and Hardy Hendren. He served as the
Director of the Laboratory for Tissue Engineering and Cellular Therapeutics at
Children's Hospital Boston. His work there involved growing human tissues
and organs to replace those damaged by disease or defects. This work became
important due to shortages in the organ-donor program. Dr.
Atala continued his work in Tissue engineering and Printable organs at Wake Forest University in 2004. Dr.
Atala led the team that developed the first lab-grown organ, a bladder, to be
implanted into a human. Aside from his ground breaking research, Dr. Atala also
tends to clinical and administrative responsibilities. He operates regularly
and runs a busy clinic at the North Carolina
Baptist Hospital, the teaching hospital of the Wake Forest
University School of Medicine. He is also in charge of a rapidly growing urology
department and has been successful in recruiting other renowned faculty to Wake
Forest such as Gopal Badlani, James Yoo and Gordon McLorie. Along with Harvard University researchers and as described in the journal Nature Biotechnology,
he has announced that stem cells with enormous potential can be harvested from
the amniotic fluid of pregnant women. These amniotic stem cells are pluripotent, meaning they can be manipulated to differentiate into
various types of mature cells that make up nerve, muscle, bone, and other
tissues while avoiding the problems of tumor formation and ethical concerns
that are associated with embryonic stem cells. With respect to the amniotic fluid stem cells
("AFS" cells), Dr. Atala said the following: "The cells come
from the fetus, which breathes and sucks in, then excretes, the amniotic fluid
throughout pregnancy;" "Like embryonic stem cells, they appear to
thrive in lab dishes for years, while normal cells, called somatic cells, die
after a time ; They are easier to grow than human embryonic stem cells.
And, unlike embryonic stem cells, they do not form a type of benign tumour
called a teratoma;" and "A bank with 100,000 specimens of the
amniotic stem cells theoretically could supply 99 per cent of the US population
with perfect genetic matches for transplants." Dr. Atala's work was seized
on by opponents of the Embryonic Stem Cell Research Bill (a part of
the 100-Hour Plan of the Democratic Party in
the 110th United States
Congress) as a more moral alternative. He wrote a letter
saying, inter alia, "Some may be interpreting my research as a
substitute for the need to pursue other forms of regenerative medicine
therapies, such as those involving embryonic stem cells. I disagree with that
assertion."