مقاله بعدی
بسم الله الرحمن الرحيم
رفقا سلام،
مطلب زير، خلاصه يک مقاله ديگر، چاپ سال ۲۰۰۶ است. اتفاقا نويسنده اصلی اين مقاله، يک خانم دکتر ايرانی است که تحقيقش را در سوئد انجام داده است. اين مقاله، گزارش اخذ سلول بنيادی از سياهرگ صفانوس پای بيماران و سپس کاشت آن سلولهای بنيادی در يک اسکافولد، به عنوان بافت زمينه نگهدارنده و داخل يک بيو رآکتور به عنوان سيستم کشت ديناميکی يا محرک رشد سلول بنياديست. در مرحله آخر آنها توانسته اند، رگ مصنوعی با منشا سلول بنيادی انسانی توليد کنند.
Production of Extracellular Matrix Components in Tissue-Engineered Blood Vessels
TISSUE ENGINEERING: Volume 12, Number 4, 2006, © Mary Ann Liebert, Inc
The key of tissue engineering is cells and repair abilities in tissue engineering is related to cell proliferation, differentiation, cell-to-cell signalling, producing of extra cellular matrix (ECM) and deposition of ECM. Deposition of ECM is necessary for graft strength. So, the ability of tissue engineering necessitates ECM. ECM contains collagen; elastin and proteoglycan which are responsible for tensile stiffness, elasticity, compressibility and combined with all of them are responsible for viscoelasticity. These are the components of mechanical property. Researchers in this study tried to seed smooth muscle cells (SMCs) and endothelial cells (ECs) which were isolated from great sephanous vein during heart by-pass surgery and put them into the poly glycolic acid (PGA) scaffold into bioreactor with pulsatile suspension of Dulbecco’s modified Eagle’s medium (DMEM) and growth factors (GF) and produced tissue engineered blood vessels (TEBVs).............................................................................