مقاله جديد
بسم الله الرحمن الرحيم
رفقا سلام،
مطلب زير، خلاصه يک مقاله ديگراز مجله بيوماتريال است که هنوز چاپ نشده است. اين مقاله، گزارش ترميم بافت استخوان، بوسيله کاشت سلول بنيادی در يک اسکافولد به عنوان بافت زمينه نگهدارنده و داخل يک بيو رآکتور به عنوان سيستم کشت ديناميکی يا محرک رشد سلول بنياديست.
Neo-vascularisation and bone formation mediated by fetal mesenchymal stem cell tissue- engineered bone grafts in critical-size femoral defects
Biomaterial 31 (2010) 608-620
Fracture injuries are common medical issues nowadays. The current strategies to prevent or treat non-union fractures; autologous bone grafts, allografts and synthetic implants, have several complications such as donor site morbidity, limited supply, immune rejection responses, less cellularity and vascularity and poor speed healing. So, tissue-engineering bone grafts (TEBG) are provided an opportunity to resolve current demerits. It provides availability in size and shape, rapid bone healing without any immune responses and successful implantation. In this study researchers used human fetal MSCs (hfMSCs), macroporous poly-ε-caprolactone tri-calcium phosphate (PCL-TCP) as a scaffold and a bioreactor as a dynamic culture system. They mentioned that hfMSCs have higher proliferative and osteogenic capacity and lower immunogenicity compared to other sources of MSCs. The scaffold has biocompatible materials, osteoinductive properties, suitable degradation and macroporous design that allow neo-vascularisation. The bioreactor as a dynamic system with rotating wall vessel has been used to improve transferring materials, to apply a mechanical stimulus to the cell’s activities and promoting osteogenic differentiation and mineralization of hfMSCs.